IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0098787.html
   My bibliography  Save this article

An 18-Gene Signature for Vascular Invasion Is Associated with Aggressive Features and Reduced Survival in Breast Cancer

Author

Listed:
  • Monica Mannelqvist
  • Elisabeth Wik
  • Ingunn M Stefansson
  • Lars A Akslen

Abstract

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients. Methods and Results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature. Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

Suggested Citation

  • Monica Mannelqvist & Elisabeth Wik & Ingunn M Stefansson & Lars A Akslen, 2014. "An 18-Gene Signature for Vascular Invasion Is Associated with Aggressive Features and Reduced Survival in Breast Cancer," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0098787
    DOI: 10.1371/journal.pone.0098787
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098787
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0098787&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0098787?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Carey K Anders & Chaitanya R Acharya & David S Hsu & Gloria Broadwater & Katherine Garman & John A Foekens & Yi Zhang & Yixin Wang & Kelly Marcom & Jeffrey R Marks & Sayan Mukherjee & Joseph R Nevins , 2008. "Age-Specific Differences in Oncogenic Pathway Deregulation Seen in Human Breast Tumors," PLOS ONE, Public Library of Science, vol. 3(1), pages 1-8, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0098787. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.