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Meta-Analysis of Randomized Controlled Trials Comparing Latanoprost with Timolol in the Treatment of Asian Populations with Chronic Angle-Closure Glaucoma

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  • Shi-Ming Li
  • Ru Chen
  • Yuan Li
  • Zhi-Rong Yang
  • Qiu-Ju Deng
  • Zheng Zhong
  • Moh-Lim Ong
  • Si-Yan Zhan

Abstract

Background: To evaluate the efficacy and safety of latanoprost compared with timolol in the treatment of Asian patients with chronic angle-closure glaucoma (CACG). Methods: Relevant trials were identified through systematic searches of Medline, EMBASE, PubMed, Cochrane Library, Google Scholar and several Chinese databases. The main outcome measures included absolute and relative reduction of intraocular pressure (IOP) at mean, peak and trough from baseline, ocular adverse effects and systemic adverse events. Results: Seven randomized controlled trials with 685 patients were included. In comparison with timolol, latanoprost reduced absolute IOP in CACG patients by more than 2.3 mmHg (95%CI, 1.8∼2.9, P

Suggested Citation

  • Shi-Ming Li & Ru Chen & Yuan Li & Zhi-Rong Yang & Qiu-Ju Deng & Zheng Zhong & Moh-Lim Ong & Si-Yan Zhan, 2014. "Meta-Analysis of Randomized Controlled Trials Comparing Latanoprost with Timolol in the Treatment of Asian Populations with Chronic Angle-Closure Glaucoma," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0096852
    DOI: 10.1371/journal.pone.0096852
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    Cited by:

    1. Lingyan Yu & Kai Ding & Lifang Luo & Zhenwei Yu, 2020. "Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-10, January.

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