IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0096710.html
   My bibliography  Save this article

Age-Related Decrease of Meiotic Cohesins in Human Oocytes

Author

Listed:
  • Makiko Tsutsumi
  • Reiko Fujiwara
  • Haruki Nishizawa
  • Mayuko Ito
  • Hiroshi Kogo
  • Hidehito Inagaki
  • Tamae Ohye
  • Takema Kato
  • Takuma Fujii
  • Hiroki Kurahashi

Abstract

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic chromosomes. In mammalian oocytes, cohesion is established during the fetal stages and meiosis-specific cohesin subunits are not replenished after birth, raising the possibility that the long meiotic arrest of oocytes facilitates a deterioration of cohesion that leads to age-related increases in aneuploidy. We here examined the cohesin levels in dictyate oocytes from different age groups of humans and mice by immunofluorescence analyses of ovarian sections. The meiosis-specific cohesin subunits, REC8 and SMC1B, were found to be decreased in women aged 40 and over compared with those aged around 20 years (P

Suggested Citation

  • Makiko Tsutsumi & Reiko Fujiwara & Haruki Nishizawa & Mayuko Ito & Hiroshi Kogo & Hidehito Inagaki & Tamae Ohye & Takema Kato & Takuma Fujii & Hiroki Kurahashi, 2014. "Age-Related Decrease of Meiotic Cohesins in Human Oocytes," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-8, May.
  • Handle: RePEc:plo:pone00:0096710
    DOI: 10.1371/journal.pone.0096710
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096710
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096710&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0096710?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sharma A & Gupta A & Tiwari M & Yadav PK & Sahu K & Prasad S & Pandey AN & Chaube SK & Pandey AK, 2018. "Oocyte Quality and Female Infertility," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 3(2), pages 29-32, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0096710. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.