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Tobacco Smoking, Alcohol Drinking, Diabetes, Low Body Mass Index and the Risk of Self-Reported Symptoms of Active Tuberculosis: Individual Participant Data (IPD) Meta-Analyses of 72,684 Individuals in 14 High Tuberculosis Burden Countries

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  • Jayadeep Patra
  • Prabhat Jha
  • Jürgen Rehm
  • Wilson Suraweera

Abstract

Background: The effects of multiple exposures on active tuberculosis (TB) are largely undetermined. We sought to establish a dose-response relationship for smoking, drinking, and body mass index (BMI) and to investigate the independent and joint effects of these and diabetes on the risk of self-reported symptoms of active TB disease. Methods and Findings: We analyzed 14 national studies in 14 high TB-burden countries using self-reports of blood in cough/phlegm and cough lasting > = 3 weeks in the last year as the measures of symptoms of active TB. The random effect estimates of the relative risks (RR) between active TB and smoking, drinking, diabetes, and BMI

Suggested Citation

  • Jayadeep Patra & Prabhat Jha & Jürgen Rehm & Wilson Suraweera, 2014. "Tobacco Smoking, Alcohol Drinking, Diabetes, Low Body Mass Index and the Risk of Self-Reported Symptoms of Active Tuberculosis: Individual Participant Data (IPD) Meta-Analyses of 72,684 Individuals in," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0096433
    DOI: 10.1371/journal.pone.0096433
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