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Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis

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  • Tong-Chun Xue
  • Lan Zhang
  • Xiao-Yin Xie
  • Ning-Ling Ge
  • Li-Xin Li
  • Bo-Heng Zhang
  • Sheng-Long Ye
  • Zheng-Gang Ren

Abstract

The neutrophil-to-lymphocyte ratio (NLR) is a useful biomarker that reflects systemic inflammation responses. However, the prognostic value of the NLR in patients with primary liver cancer (PLC) remains controversial. We performed a meta-analysis of 26 studies (comprising 4,461 patients) to evaluate the association between the pre-treatment NLR and clinical outcomes of overall survival (OS) and disease-free survival (DFS) in patients with PLC. The correlation between NLR and tumor characteristics or other inflammation-related parameters was also assessed. Data were synthesized using the random-effects model of DerSimonian and Laird, and the hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was used to estimate effect size. Our analysis indicated that a high NLR predicted poor OS (HR, 2.102; 95% CI: 1.741–2.538) and DFS (HR, 2.474; 95% CI: 1.855–3.300) for PLC. A high NLR was associated with the presence of tumor vascular invasion (OR: 1.889, 95% CI: 1.487–2.400; p

Suggested Citation

  • Tong-Chun Xue & Lan Zhang & Xiao-Yin Xie & Ning-Ling Ge & Li-Xin Li & Bo-Heng Zhang & Sheng-Long Ye & Zheng-Gang Ren, 2014. "Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0096072
    DOI: 10.1371/journal.pone.0096072
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    Cited by:

    1. Yukinori Takenaka & Takahiro Kitamura & Ryohei Oya & Naoki Ashida & Kotaro Shimizu & Kazuya Takemura & Yoshifumi Yamamoto & Atsuhiko Uno, 2017. "Prognostic role of neutrophil–lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-12, July.
    2. Song Yue & Jiahua Zhang & Jingyang Wu & Weiping Teng & Lei Liu & Lei Chen, 2015. "Use of the Monocyte-to-Lymphocyte Ratio to Predict Diabetic Retinopathy," IJERPH, MDPI, vol. 12(8), pages 1-11, August.

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