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L-Type Ca2+ Channel Sparklets Revealed by TIRF Microscopy in Mouse Urinary Bladder Smooth Muscle

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  • Peter Sidaway
  • Noriyoshi Teramoto

Abstract

Calcium is a ubiquitous second messenger in urinary bladder smooth muscle (UBSM). In this study, small discrete elevations of intracellular Ca2+, referred to as Ca2+ sparklets have been detected in an intact detrusor smooth muscle electrical syncytium using a TIRF microscopy Ca2+ imaging approach. Sparklets were virtually abolished by the removal of extracellular Ca2+ (0.035±0.01 vs. 0.23±0.07 Hz/mm2; P

Suggested Citation

  • Peter Sidaway & Noriyoshi Teramoto, 2014. "L-Type Ca2+ Channel Sparklets Revealed by TIRF Microscopy in Mouse Urinary Bladder Smooth Muscle," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0093803
    DOI: 10.1371/journal.pone.0093803
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    References listed on IDEAS

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    1. Shi-Qiang Wang & Long-Sheng Song & Edward G. Lakatta & Heping Cheng, 2001. "Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells," Nature, Nature, vol. 410(6828), pages 592-596, March.
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