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Predictors of Two Months Culture Conversion in Multidrug-Resistant Tuberculosis: Findings from a Retrospective Cohort Study

Author

Listed:
  • Anila Basit
  • Nafees Ahmad
  • Amer Hayat Khan
  • Arshad Javaid
  • Syed Azhar Syed Sulaiman
  • Afsar Khan Afridi
  • Azreen Syazril Adnan
  • Israr ul Haq
  • Syed Saleem Shah
  • Ahmed Ahadi
  • Izaz Ahmad

Abstract

Background: Various studies have reported culture conversion at two months as a predictor of successful treatment outcome in multidrug-resistant tuberculosis (MDR-TB). Objectives: The present study was conducted with the aim to evaluate the rate and predictors of culture conversion at two months in MDR-TB patients. Methods: All confirmed pulmonary MDR-TB patients enrolled for treatment at Lady Reading Hospital Peshawar, Pakistan from 1 January to 31 December 2012 and met the inclusion criteria were reviewed retrospectively. Rate and predictors of culture conversion at two months were evaluated. Results: Eighty seven (53.4%) out of 163 patients achieved culture conversion at two months. In a multivariate analysis lung cavitation at baseline chest X-ray (P = 0.006, OR = 0.349), resistance to ofloxacin (P = 0.041, OR = 0.193) and streptomycin (P = 0.017, OR = 0.295) had statistically significant (P

Suggested Citation

  • Anila Basit & Nafees Ahmad & Amer Hayat Khan & Arshad Javaid & Syed Azhar Syed Sulaiman & Afsar Khan Afridi & Azreen Syazril Adnan & Israr ul Haq & Syed Saleem Shah & Ahmed Ahadi & Izaz Ahmad, 2014. "Predictors of Two Months Culture Conversion in Multidrug-Resistant Tuberculosis: Findings from a Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0093206
    DOI: 10.1371/journal.pone.0093206
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    1. William A Wells & Colin Fan Ge & Nitin Patel & Teresa Oh & Elizabeth Gardiner & Michael E Kimerling, 2011. "Size and Usage Patterns of Private TB Drug Markets in the High Burden Countries," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.
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