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Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells

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Listed:
  • Ning Wang
  • Yuanyong Feng
  • Qingjie Wang
  • Shaohua Liu
  • Lei Xiang
  • Mingxia Sun
  • Xiaoying Zhang
  • Guixiang Liu
  • Xun Qu
  • Fengcai Wei

Abstract

Objective: The present study aimed to explore the clinical significance of neutrophils infiltration and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) expression in the tongue squamous cell carcinoma (TSCC), and to probe the possible relationship between them. Materials and Methods: Tissue microarray and immunohistochemistry were used to detect neutrophils density and CEACAM1 expression in 74 cases of primary TSCC specimens and 17 cases of corresponding peritumoral tissues. The relationship of CEACAM1 expression and neutrophils density with clinicopathologic parameters and cancer-related survival of TSCC patients were evaluated. The correlation between CEACAM1 expression and neutrophils density was also evaluated. Real-time quantitative transcription polymerase chain reaction (qRT-PCR) was used to explore the possible molecular mechanisms between CEACAM1 expression and neutrophils infiltration. Results: Immunohistochemistry evaluation revealed that there was more neutrophils infiltration in TSCC tissues than in peritumoral tissues. High neutrophil density was associated with LN metastasis (P = 0.01), higher clinical stage (P = 0.037) and tumor recurrence (P = 0.024). CEACAM1 overexpression was also associated with lymph node metastasis (P = 0.000) and higher clinical stage (P = 0.001). Survival analysis revealed that both neutrophils infiltration and CEACAM1 overexpression were associated with poorer cancer-related survival of TSCC patients (P

Suggested Citation

  • Ning Wang & Yuanyong Feng & Qingjie Wang & Shaohua Liu & Lei Xiang & Mingxia Sun & Xiaoying Zhang & Guixiang Liu & Xun Qu & Fengcai Wei, 2014. "Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0089991
    DOI: 10.1371/journal.pone.0089991
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    1. Jing-jing Zhao & Ke Pan & Wei Wang & Ju-gao Chen & Yan-heng Wu & Lin Lv & Jian-jun Li & Yi-bing Chen & Dan-dan Wang & Qiu-zhong Pan & Xiao-dong Li & Jian-chuan Xia, 2012. "The Prognostic Value of Tumor-Infiltrating Neutrophils in Gastric Adenocarcinoma after Resection," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-6, March.
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