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Elevated Expression of miR-210 Predicts Poor Survival of Cancer Patients: A Systematic Review and Meta-Analysis

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  • Jian Wang
  • Jiqing Zhao
  • Mengjing Shi
  • Yu Ding
  • Huiqin Sun
  • Fahuan Yuan
  • Zhongmin Zou

Abstract

Background: MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers. Methodology/Principal Findings: The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85–2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30–2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05–1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14–9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47–5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90–4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20–7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27–4.94, P = 0.842). Conclusions/Significance: This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.

Suggested Citation

  • Jian Wang & Jiqing Zhao & Mengjing Shi & Yu Ding & Huiqin Sun & Fahuan Yuan & Zhongmin Zou, 2014. "Elevated Expression of miR-210 Predicts Poor Survival of Cancer Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0089223
    DOI: 10.1371/journal.pone.0089223
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    Cited by:

    1. Yanyan Wang & Yujie Zhang & Chi Pan & Feixia Ma & Suzhan Zhang, 2015. "Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.

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