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Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions

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  • Jacqueline Deen
  • Mohammad Ali
  • David Sack

Abstract

There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.

Suggested Citation

  • Jacqueline Deen & Mohammad Ali & David Sack, 2014. "Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0088139
    DOI: 10.1371/journal.pone.0088139
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    References listed on IDEAS

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    1. Ira M Longini Jr. & Azhar Nizam & Mohammad Ali & Mohammad Yunus & Neeta Shenvi & John D Clemens, 2007. "Controlling Endemic Cholera with Oral Vaccines," PLOS Medicine, Public Library of Science, vol. 4(11), pages 1-8, November.
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