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Statin Use Is Associated with Reduced Risk of Haematological Malignancies: Evidence from a Meta-Analysis

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  • Xiao Yi
  • Wei Jia
  • Yin Jin
  • Shang Zhen

Abstract

Background: Several observational studies have shown that statin use may modify the risk of haematological malignancies. To quantify the association between statin use and risk for haematological malignancies, we performed a detailed meta-analysis of published studies regarding this subject. Methods: We conducted a systematic search of multiple databases including PubMed, Embase, and Cochrane Library Central database up to July 2013. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression. Subgroup analyses and sensitivity analysis were also performed. Results: A total of 20 eligible studies (ten case-control studies, four cohort studies, and six RCTs) reporting 1,139,584 subjects and 15,297 haematological malignancies cases were included. Meta-analysis showed that statin use was associated with a statistically significant 19% reduction in haematological malignancies incidence (RR = 0.81, 95% CI [0.70, 0.92]). During subgroup analyses, statin use was associated with a significantly reduced risk of haematological malignancies among observational studies (RR = 0.79, 95% CI [0.67, 0.93]), but not among RCTs (RR = 0.92, 95% CI [0.77, 1.09]). Conclusions: Based on this comprehensive meta-analysis, statin use may have chemopreventive effects against haematological malignancies. More studies, especially definitive, randomized chemoprevention trials are needed to confirm this association.

Suggested Citation

  • Xiao Yi & Wei Jia & Yin Jin & Shang Zhen, 2014. "Statin Use Is Associated with Reduced Risk of Haematological Malignancies: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0087019
    DOI: 10.1371/journal.pone.0087019
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    1. Dipika Bansal & Krishna Undela & Sanjay D'Cruz & Fabrizio Schifano, 2012. "Statin Use and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-11, October.
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