IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0087017.html
   My bibliography  Save this article

Association between APOC1 Polymorphism and Alzheimer’s Disease: A Case-Control Study and Meta-Analysis

Author

Listed:
  • Qin Zhou
  • Fan Zhao
  • Ze-ping Lv
  • Chen-guang Zheng
  • Wei-dong Zheng
  • Liang Sun
  • Na-na Wang
  • Shenghang Pang
  • Fabiana Michelsen de Andrade
  • Mian Fu
  • Xiang-hua He
  • Juan Hui
  • Wen-yu Jiang
  • Chu-yu Yang
  • Xiao-hong Shi
  • Xiao-quan Zhu
  • Guo-fang Pang
  • Yi-ge Yang
  • Hai-qun Xie
  • Wan-dong Zhang
  • Cai-you Hu
  • Ze Yang

Abstract

Background: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer’s disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations. Methods: To confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies. Results: Seventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE ε4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ2 = 119.46, OR = 2.79, 95% CI = 2.31–3.36, P

Suggested Citation

  • Qin Zhou & Fan Zhao & Ze-ping Lv & Chen-guang Zheng & Wei-dong Zheng & Liang Sun & Na-na Wang & Shenghang Pang & Fabiana Michelsen de Andrade & Mian Fu & Xiang-hua He & Juan Hui & Wen-yu Jiang & Chu-y, 2014. "Association between APOC1 Polymorphism and Alzheimer’s Disease: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0087017
    DOI: 10.1371/journal.pone.0087017
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087017
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087017&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0087017?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Smita Majumder & Arlan Richardson & Randy Strong & Salvatore Oddo, 2011. "Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-11, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. You Li & Yongquan Huang & Xue Liang & Bingshuang Long & Shiyi Chen & Jiahao Lian & Yi Wei & Zhiyong Zhang & Jian Qin, 2017. "Apolipoprotein C-I Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Population," IJERPH, MDPI, vol. 14(5), pages 1-10, May.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0087017. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.