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Age-Dependent Prevalence of Nasopharyngeal Carriage of Streptococcus pneumoniae before Conjugate Vaccine Introduction: A Prediction Model Based on a Meta-Analysis

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  • Olivier Le Polain de Waroux
  • Stefan Flasche
  • David Prieto-Merino
  • W John Edmunds

Abstract

Introduction: Data on the prevalence of nasopharyngeal carriage of S.pneumoniae in all age groups are important to help predict the impact of introducing pneumococcal conjugate vaccines (PCV) into routine infant immunization, given the important indirect effect of the vaccine. Yet most carriage studies are limited to children under five years of age. We here explore the association between carriage prevalence and serotype distribution in children aged ≥5 years and in adults compared to children. Methods: We conducted a systematic review of studies providing carriage estimates across age groups in healthy populations not previously exposed to PCV, using MEDLINE and Embase. We used Bayesian linear meta-regression models to predict the overall carriage prevalence as well as the prevalence and distribution of vaccine and nonvaccine type (VT and NVT) serotypes in older age groups as a function of that in

Suggested Citation

  • Olivier Le Polain de Waroux & Stefan Flasche & David Prieto-Merino & W John Edmunds, 2014. "Age-Dependent Prevalence of Nasopharyngeal Carriage of Streptococcus pneumoniae before Conjugate Vaccine Introduction: A Prediction Model Based on a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    • Handle: RePEc:plo:pone00:0086136
    DOI: 10.1371/journal.pone.0086136
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    Cited by:

    1. Stefan Flasche & Olivier Le Polain de Waroux & Katherine L O’Brien & W John Edmunds, 2015. "The Serotype Distribution among Healthy Carriers before Vaccination Is Essential for Predicting the Impact of Pneumococcal Conjugate Vaccine on Invasive Disease," PLOS Computational Biology, Public Library of Science, vol. 11(4), pages 1-15, April.

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