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Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies

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  • Min-Li Chen
  • Ning Liao
  • Hua Zhao
  • Jian Huang
  • Zheng-Fu Xie

Abstract

Background: Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association. Methods: We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI). Results: A total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76–0.97, Pz = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81–1.12, Pz = 0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60–1.12, Pz = 0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR = 0.68, 95% CI: 0.55–0.84, Pz

Suggested Citation

  • Min-Li Chen & Ning Liao & Hua Zhao & Jian Huang & Zheng-Fu Xie, 2014. "Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0086077
    DOI: 10.1371/journal.pone.0086077
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    1. Shuang-Xia Zhao & Chun-Ming Pan & Huang-Ming Cao & Bing Han & Jing-Yi Shi & Jun Liang & Guan-Qi Gao & Yong-De Peng & Qing Su & Jia-Lun Chen & Jia-Jun Zhao & Huai-Dong Song, 2010. "Association of the CTLA4 Gene with Graves' Disease in the Chinese Han Population," PLOS ONE, Public Library of Science, vol. 5(3), pages 1-10, March.
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