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MspI and Ile462Val Polymorphisms in CYP1A1 and Overall Cancer Risk: A Meta-Analysis

Author

Listed:
  • Bin Wu
  • Kang Liu
  • Huaxing Huang
  • Jun Yuan
  • Wanqing Yuan
  • Shangqian Wang
  • Tingting Chen
  • Hu Zhao
  • Changjun Yin

Abstract

Background: Cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family, which is a key enzyme in the metabolism of many endogenous substrates and exogenous carcinogens. To date, many studies have examined the association between CYP1A1 MspI and Ile462Val polymorphisms and cancer risk in various populations, but their results have been conflicting rather than consistent. Methods: To assess this relationship more precisely, a meta-analysis based on 198 publications was performed. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with a chi-square-based Q-test. Results: Overall, a significant elevated risk of cancer was associated with CYP1A1 MspI and Ile462Val polymorphisms for all genetic models studied. Further stratified analysis by cancer types revealed that the MspI polymorphism may increase the risk of lung cancer and cervical cancer whereas the Ile462Val polymorphism may contribute to a higher risk of lung cancer, leukemia, esophageal carcinoma, and prostate cancer. In the subgroup analysis by ethnicity, obvious associations were found in the Asian population for the MspI polymorphism while an increased risk of cancer was observed in Asians and Caucasians for the Ile462Val polymorphism. Conclusions: The results of this meta-analysis suggest that CYP1A1 MspI and Ile462Val polymorphisms contribute to increased cancer susceptibility among Asians. Additional comprehensive system analyses are required to validate this association and other related polymorphisms.

Suggested Citation

  • Bin Wu & Kang Liu & Huaxing Huang & Jun Yuan & Wanqing Yuan & Shangqian Wang & Tingting Chen & Hu Zhao & Changjun Yin, 2013. "MspI and Ile462Val Polymorphisms in CYP1A1 and Overall Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0085166
    DOI: 10.1371/journal.pone.0085166
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    1. Ting Wang & Yang Liu & Li Sima & Liang Shi & Zhaoming Wang & Chunhui Ni & Zhengdong Zhang & Meilin Wang, 2012. "Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
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