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A Genetic Association Study of CCL5 -28 C>G (rs2280788) Polymorphism with Risk of Tuberculosis: A Meta-Analysis

Author

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  • Mohammed A A Alqumber
  • Raju K Mandal
  • Shafiul Haque
  • Aditya K Panda
  • Naseem Akhter
  • Arif Ali

Abstract

Aim: The CC chemokine ligand 5 (CCL5), plays a key role in the inflammatory response by recruiting mononuclear cells during tuberculosis (TB) infection. Association studies of CCL5 -28 C>G (rs2280788) polymorphism and TB risk have shown inconsistent and contradictory results among different ethnic populations. The aim of this meta-analysis is to investigate the association between CCL5 -28 C>G polymorphism and TB susceptibility. Methodology: We performed quantitative synthesis for published studies based upon association between CCL5 -28 C>G polymorphism and TB risk from PubMed (Medline), EMBASE web databases. The meta-analysis was performed and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all genetic models. Results: A total of six studies including 1324 TB cases and 1407 controls were involved in this meta-analysis. Variant allele (G vs. C: p = 0.257; OR = 1.809, 95% CI = 0.649 to 5.043), heterozygous (CG vs. CC: p = 0.443; OR = 1.440, 95% CI = 0.567 to 3.658) and homozygous (GG vs. CC: p = 0.160; OR = 5.140, 95% CI = 0.524 to 50.404) carriers did not show increased risk compare with those individual with the CC genotype. Similarly, no associations were found in the dominant (GG+CG vs. CC: p = 0.295; OR = 1.802, 95% CI = 0.599 to 5.412) and recessive (GG vs. CC+CG: p = 0.188; OR = 3.533, 95% CI = 0.541 to 23.085) models. Conclusions: Overall findings of this meta-analysis suggest that genetic polymorphism -28 C>G in CCL5 is not associated with increased TB risk. However, future larger studies with group of populations will be needed to analyze the relationship between the CCL5 -28 C>G polymorphism and risk of TB.

Suggested Citation

  • Mohammed A A Alqumber & Raju K Mandal & Shafiul Haque & Aditya K Panda & Naseem Akhter & Arif Ali, 2013. "A Genetic Association Study of CCL5 -28 C>G (rs2280788) Polymorphism with Risk of Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0083422
    DOI: 10.1371/journal.pone.0083422
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    1. Wu Rongling & Bailian Li, 1999. "A Multiplicative-Epistatic Model for Analyzing Interspecific Differences in Outcrossing Species," Biometrics, The International Biometric Society, vol. 55(2), pages 355-365, June.
    2. MY Areeshi & Raju K Mandal & Aditya K Panda & Shekhar C Bisht & Shafiul Haque, 2013. "CD14 −159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
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