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Increased Basal and Alum-Induced Interleukin-6 Levels in Geriatric Patients Are Associated with Cardiovascular Morbidity

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Listed:
  • Nathalie Compté
  • Karim Zouaoui Boudjeltia
  • Michel Vanhaeverbeek
  • Sandra De Breucker
  • Thierry Pepersack
  • Joel Tassignon
  • Anne Trelcat
  • Stanislas Goriely

Abstract

Background/Aim of the study: Low-grade systemic inflammation was suggested to participate to the decline of physiological functions and increased vulnerability encountered in older patients. Geriatric syndromes encompass various features such as functional dependence, polymorbidity, depression and malnutrition. There is a strong prevalence of cardiovascular diseases and related risk factors and chronic cytomegalovirus infections in the geriatric population. As these underlying conditions were proposed to influence the inflammatory state, the aim of this study was to assess their potential contribution to the association of geriatric syndromes with inflammatory parameters. Methodology: We recruited 100 subjects in the general population or hospitalized for chronic medical conditions (age, 23-96 years). We collected information on clinical status (medical history, ongoing comorbidities, treatments and geriatric scales), biological parameters (hematological tests, cytomegalovirus serology) and cytokines production (basal and alum-induced interleukin (IL)-1β and IL-6 levels). Using stepwise backward multivariate analyses, we defined which set of clinical and biological variables could be predictive for increased inflammatory markers. Principal Findings: We confirmed the age-associated increase of circulating IL-6 levels. In contrast to geriatric scales, we found history of cardiovascular diseases to be strongly associated for this parameter as for high IL-6 production upon ex vivo stimulation with alum. Conclusions: Association between low-grade inflammation and geriatric conditions could be linked to underlying cardiovascular diseases.

Suggested Citation

  • Nathalie Compté & Karim Zouaoui Boudjeltia & Michel Vanhaeverbeek & Sandra De Breucker & Thierry Pepersack & Joel Tassignon & Anne Trelcat & Stanislas Goriely, 2013. "Increased Basal and Alum-Induced Interleukin-6 Levels in Geriatric Patients Are Associated with Cardiovascular Morbidity," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0081911
    DOI: 10.1371/journal.pone.0081911
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    References listed on IDEAS

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    1. Guo-hua Zheng & Hai-ying Chen & Shang-Quan Xiong, 2012. "Polymorphisms of −174G>C and −572G>C in the Interleukin 6 (IL-6) Gene and Coronary Heart Disease Risk: A Meta-Analysis of 27 Research Studies," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-8, April.
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