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Association between GRIN3A Gene Polymorphism in Kawasaki Disease and Coronary Artery Aneurysms in Taiwanese Children

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Listed:
  • Ying-Ju Lin
  • Jeng-Sheng Chang
  • Xiang Liu
  • Chien-Hui Hung
  • Ting-Hsu Lin
  • Shao-Mei Huang
  • Kuan-Teh Jeang
  • Chia-Yen Chen
  • Chiu-Chu Liao
  • Cheng-Wen Lin
  • Chih-Ho Lai
  • Ni Tien
  • Yu-Ching Lan
  • Mao-Wang Ho
  • Wen-Kuei Chien
  • Jin-Hua Chen
  • Yu-Chuen Huang
  • Hsinyi Tsang
  • Jer-Yuarn Wu
  • Chien-Hsiun Chen
  • Li-Ching Chang
  • Fuu-Jen Tsai

Abstract

Kawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A (GRIN3A) in KD, we investigated genetic variations in GRIN3A in a Taiwanese cohort of 262 KD patients (76 with and 186 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between clinical characteristics and GRIN3A genetic variations in KD. According to univariate regression analysis, CAA formation in KD was significantly associated with fever duration (p

Suggested Citation

  • Ying-Ju Lin & Jeng-Sheng Chang & Xiang Liu & Chien-Hui Hung & Ting-Hsu Lin & Shao-Mei Huang & Kuan-Teh Jeang & Chia-Yen Chen & Chiu-Chu Liao & Cheng-Wen Lin & Chih-Ho Lai & Ni Tien & Yu-Ching Lan & Ma, 2013. "Association between GRIN3A Gene Polymorphism in Kawasaki Disease and Coronary Artery Aneurysms in Taiwanese Children," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0081384
    DOI: 10.1371/journal.pone.0081384
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    1. Hiroyasu Furukawa & Satinder K Singh & Romina Mancusso & Eric Gouaux, 2005. "Subunit arrangement and function in NMDA receptors," Nature, Nature, vol. 438(7065), pages 185-192, November.
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