IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0080991.html
   My bibliography  Save this article

Causes and Outcomes of Acute Liver Failure in China

Author

Listed:
  • Pan Zhao
  • Chunya Wang
  • Weiwei Liu
  • Gang Chen
  • Xinying Liu
  • Xi Wang
  • Bao Wang
  • Liming Yu
  • Yanrong Sun
  • Xiaoming Liang
  • Haozhen Yang
  • Fei Zhang

Abstract

Objectives: No extensive investigation has been performed and thus no representative data are available regarding acute liver failure (ALF) in China. This study aims to investigate the causes and outcomes of ALF in China and establish a prognostic model. Methods: Patients diagnosed as ALF in seven hospitals in different areas of China from January 2007 to December 2012 were retrospectively selected. Results: Of the 177 patients included in this study, 112 (63.28%) eventually died. The common causes of ALF were drug toxicity (43.50%), indeterminate etiology (29.38%) and acute viral hepatitis (11.30%). Additionally, traditional Chinese herbs predominated in the causes of drug-induced ALF (30/77). No patients in this study received liver transplantation. In the established model for predicting death in ALF, four variables were finally selected out, including age (P=0.01), the entry hepatic encephalopathy grade (P=0.04), international normalized ratio (P

Suggested Citation

  • Pan Zhao & Chunya Wang & Weiwei Liu & Gang Chen & Xinying Liu & Xi Wang & Bao Wang & Liming Yu & Yanrong Sun & Xiaoming Liang & Haozhen Yang & Fei Zhang, 2013. "Causes and Outcomes of Acute Liver Failure in China," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0080991
    DOI: 10.1371/journal.pone.0080991
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080991
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080991&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0080991?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kama A Wlodzimirow & Saeid Eslami & Robert A F M Chamuleau & Martin Nieuwoudt & Ameen Abu-Hanna, 2012. "Prediction of Poor Outcome in Patients with Acute Liver Failure—Systematic Review of Prediction Models," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tetsu Ohnuma & Shigehiko Uchino, 2017. "Prediction Models and Their External Validation Studies for Mortality of Patients with Acute Kidney Injury: A Systematic Review," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-14, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0080991. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.