IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0080426.html
   My bibliography  Save this article

Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis

Author

Listed:
  • Xiaochun Xia
  • Baixia Yang
  • Xiaogang Zhai
  • Xiangyang Liu
  • Kang Shen
  • Zhijun Wu
  • Jing Cai

Abstract

Background: To date, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. The present meta-analysis summarizes the recent advances in the use of microRNA-21 (miR-21) in the assessment of colorectal cancer and analyzes the prognostic role of miR-21 for survival outcome. Methodology/Principal Findings: The present meta-analysis was performed by searching PubMed through multiple search strategies. Data were extracted from studies comparing overall survival (OS) in patients with colorectal cancer who showed higher expression of miR-21 than similar patients. Pooled hazard ratios (HRs) of miR-21 for survival and 95% confidence intervals (CI) were calculated. Seven studies with a total of 1174 patients were included this meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-21 expression in colorectal cancer was 1.76 (95% CI: 1.34–2.32, P=0.000). After elimination of heterogeneity, the pooled HR was 2.32 (95% CI: 1.82–2.97, P=0.000), which was found to significantly predict poorer survival. The subgroup analysis suggested that elevated miR-21 level and patients’ survival correlated with III/IV stage (HR=5.35, 95% CI: 3.73–7.66). Conclusions/Significance: The present findings suggest that high expression of miR-21 might predict poor prognosis in patients with colorectal cancer.

Suggested Citation

  • Xiaochun Xia & Baixia Yang & Xiaogang Zhai & Xiangyang Liu & Kang Shen & Zhijun Wu & Jing Cai, 2013. "Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
  • Handle: RePEc:plo:pone00:0080426
    DOI: 10.1371/journal.pone.0080426
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080426
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080426&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0080426?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lingzi Xia & Yangwu Ren & Xue Fang & Zhihua Yin & Xuelian Li & Wei Wu & Peng Guan & Baosen Zhou, 2014. "Prognostic Role of Common MicroRNA Polymorphisms in Cancers: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    2. Yanyan Wang & Yujie Zhang & Chi Pan & Feixia Ma & Suzhan Zhang, 2015. "Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0080426. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.