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HIF-1α 1772 C/T and 1790 G/A Polymorphisms Are Significantly Associated with Higher Cancer Risk: An Updated Meta-Analysis from 34 Case-Control Studies

Author

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  • Xi Yang
  • Hong-Cheng Zhu
  • Chi Zhang
  • Qin Qin
  • Jia Liu
  • Li-Ping Xu
  • Lian-Jun Zhao
  • Qu Zhang
  • Jing Cai
  • Jian-Xin Ma
  • Hong-Yan Cheng
  • Xin-Chen Sun

Abstract

Background: HIF-1 activates various genes in cancer progression and metastasis. HIF-1α 1772 C/T and 1790 G/A polymorphisms are reportedly associated with cancer risk; however, the results are inconclusive. Methodology/Principal Findings: A meta-analysis of 34 studies that involved 7522 cases and 9847 controls for 1772 C/T and 24 studies that involved 4884 cases and 8154 controls for 1790 G/A was conducted to identify the association of C/T and G/A polymorphisms with cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Conclusions: HIF-1α 1772 C/T and 1790 G/A polymorphisms are significantly associated with higher cancer risk.

Suggested Citation

  • Xi Yang & Hong-Cheng Zhu & Chi Zhang & Qin Qin & Jia Liu & Li-Ping Xu & Lian-Jun Zhao & Qu Zhang & Jing Cai & Jian-Xin Ma & Hong-Yan Cheng & Xin-Chen Sun, 2013. "HIF-1α 1772 C/T and 1790 G/A Polymorphisms Are Significantly Associated with Higher Cancer Risk: An Updated Meta-Analysis from 34 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0080396
    DOI: 10.1371/journal.pone.0080396
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    1. Dawei Li & Jikai Liu & Wenhua Zhang & Juchao Ren & Lei Yan & Hainan Liu & Zhonghua Xu, 2013. "Association between HIF1A P582S and A588T Polymorphisms and the Risk of Urinary Cancers: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
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