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High Morbidity during Treatment and Residual Pulmonary Disability in Pulmonary Tuberculosis: Under-Recognised Phenomena

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Listed:
  • Anna P Ralph
  • Enny Kenangalem
  • Govert Waramori
  • Gysje J Pontororing
  • Sandjaja
  • Emiliana Tjitra
  • Graeme P Maguire
  • Paul M Kelly
  • Nicholas M Anstey

Abstract

Background: In pulmonary tuberculosis (PTB), morbidity during treatment and residual pulmonary disability can be under-estimated. Methods: Among adults with smear-positive PTB at an outpatient clinic in Papua, Indonesia, we assessed morbidity at baseline and during treatment, and 6-month residual disability, by measuring functional capacity (six-minute walk test [6MWT] and pulmonary function), quality of life (St George’s Respiratory Questionnaire [SGRQ]) and Adverse Events ([AE]: new symptoms not present at outset). Results were compared with findings in locally-recruited volunteers. Results: 200 PTB patients and 40 volunteers were enrolled. 6WMT was 497m (interquartile range 460-529) in controls versus 408m (IQR 346-450) in PTB patients at baseline (p

Suggested Citation

  • Anna P Ralph & Enny Kenangalem & Govert Waramori & Gysje J Pontororing & Sandjaja & Emiliana Tjitra & Graeme P Maguire & Paul M Kelly & Nicholas M Anstey, 2013. "High Morbidity during Treatment and Residual Pulmonary Disability in Pulmonary Tuberculosis: Under-Recognised Phenomena," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0080302
    DOI: 10.1371/journal.pone.0080302
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    1. Anna P Ralph & Govert Waramori & Gysje J Pontororing & Enny Kenangalem & Andri Wiguna & Emiliana Tjitra & Sandjaja & Dina B Lolong & Tsin W Yeo & Mark D Chatfield & Retno K Soemanto & Ivan Bastian & R, 2013. "L-arginine and Vitamin D Adjunctive Therapies in Pulmonary Tuberculosis: A Randomised, Double-Blind, Placebo-Controlled Trial," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-12, August.
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