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Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis

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  • Jinzhao Zhao
  • Kun Miao
  • Haoran Wang
  • Hu Ding
  • Dao Wen Wang

Abstract

Background: Several epidemiological studies have examined the association between shortened telomere length and type 2 diabetes mellitus (T2DM), while the results remained conflicting. We conducted a meta-analysis to derive a more precise estimation of the relationship between them. Methods: We systematically reviewed the databases of PubMed, EMBASE, and Web of Science for all studies on the association between telomere length and T2DM. We conducted this study assessed by STATA 11.0. Data were summarized using random-effects or fixed-effects meta-analysis. The heterogeneity and publication bias among studies were examined by using χ2-based Q statistic test and Egger’s test, respectively. Results: Nine cohorts consisting of 5759 cases and 6518 controls were selected into the meta-analysis. The results indicated that shortened telomere length was significantly associated with T2DM risk (OR: 1.291; 95% CI: 1.112, 1.498; P

Suggested Citation

  • Jinzhao Zhao & Kun Miao & Haoran Wang & Hu Ding & Dao Wen Wang, 2013. "Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0079993
    DOI: 10.1371/journal.pone.0079993
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    Cited by:

    1. Daniel Nettle & Luise Seeker & Dan Nussey & Hannah Froy & Melissa Bateson, 2019. "Consequences of measurement error in qPCR telomere data: A simulation study," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-17, May.
    2. Peter Willeit & Julia Raschenberger & Emma E Heydon & Sotirios Tsimikas & Margot Haun & Agnes Mayr & Siegfried Weger & Joseph L Witztum & Adam S Butterworth & Johann Willeit & Florian Kronenberg & Ste, 2014. "Leucocyte Telomere Length and Risk of Type 2 Diabetes Mellitus: New Prospective Cohort Study and Literature-Based Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.

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