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Polymorphisms in XPD Gene Could Predict Clinical Outcome of Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer Patients: A Meta-Analysis of 24 Studies

Author

Listed:
  • Qin Qin
  • Chi Zhang
  • Xi Yang
  • Hongcheng Zhu
  • Baixia Yang
  • Jing Cai
  • Hongyan Cheng
  • Jianxin Ma
  • Jing Lu
  • Liangliang Zhan
  • Jia Liu
  • Zheming Liu
  • Liping Xu
  • Xinchen Sun

Abstract

Objective: Xeroderma pigmentosum group D (XPD) is an essential gene involved in the nucleotide excision repair (NER) pathway. Two commonly studied single nucleotide polymorphisms (SNPs) of XPD (Lys751Gln, A>C, rs13181; Asp312Asn, G>A, rs1799793) are implicated in the modulation of DNA repair capacity, thus related to the responses to platinum-based chemotherapy. Here we performed a meta-analysis to better evaluate the association between the two XPD SNPs and clinical outcome of platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients. Methods: A comprehensive search of PubMed database was conducted to identify relevant articles. Primary outcomes included objective response (i.e., complete response + partial response vs. stable disease + progressive disease), progression-free survival (PFS) and overall survival (OS). The pooled and 95% confidence intervals (CIs) of ORs (odds ratios) and HRs (hazard ratios) were estimated using the fixed or random effect model. Results: Twenty-four studies were eligible according to the inclusion criteria. None of the XPD Lys751Gln/Asp312Asn polymorphisms was associated with objective response, PFS or OS in NSCLC patients treated with platinum drugs. However, in stratified analysis by ethnicity, the XPD Lys751Gln (A>C) polymorphism was not significantly associated with increased response in Caucasians (OR = 1.35, 95%CI = 1.0–1.83, P = 0.122 for heterogeneity) but was associated with decreased PFS in Asians (HR = 1.39, 95%CI = 1.07–1.81, P = 0.879 for heterogeneity). Furthermore, a statistically significant difference existed in the estimates of effect between the two ethnicities (P = 0.014 for TR; P C) may have inverse predictive and prognostic role in platinum-based treatment of NSCLC according to different ethnicities. Further studies are needed to validate our findings.

Suggested Citation

  • Qin Qin & Chi Zhang & Xi Yang & Hongcheng Zhu & Baixia Yang & Jing Cai & Hongyan Cheng & Jianxin Ma & Jing Lu & Liangliang Zhan & Jia Liu & Zheming Liu & Liping Xu & Xinchen Sun, 2013. "Polymorphisms in XPD Gene Could Predict Clinical Outcome of Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer Patients: A Meta-Analysis of 24 Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-11, November.
  • Handle: RePEc:plo:pone00:0079864
    DOI: 10.1371/journal.pone.0079864
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    References listed on IDEAS

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    1. Juntao Ke & Rong Zhong & Ti Zhang & Lifeng Liu & Rui Rui & Na Shen & Yu Sun & Li Liu & Liming Cheng & Xiao-Ping Miao, 2013. "Replication Study in Chinese Population and Meta-Analysis Supports Association of the 5p15.33 Locus with Lung Cancer," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    2. Mantang Qiu & Xin Yang & Jingwen Hu & Xiangxiang Ding & Feng Jiang & Rong Yin & Lin Xu, 2013. "Predictive Value of XPD Polymorphisms on Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-8, August.
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    1. Mantang Qiu & Xin Yang & Jingwen Hu & Xiangxiang Ding & Feng Jiang & Rong Yin & Lin Xu, 2013. "Predictive Value of XPD Polymorphisms on Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-8, August.

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