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High-Pass Filter Characteristics of the Baroreflex – A Comparison of Frequency Domain and Pharmacological Methods

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  • Istvan Bonyhay
  • Marcelo Risk
  • Roy Freeman

Abstract

Pharmacological methods to assess baroreflex sensitivity evoke supra-physiological blood pressure changes whereas computational methods use spontaneous fluctuations of blood pressure. The relationships among the different baroreflex assessment methods are still not fully understood. Although strong advocates for each technique exist, the differences between these methods need further clarification. Understanding the differences between pharmacological and spontaneous baroreflex methods could provide important insight into the baroreflex physiology. We compared the modified Oxford baroreflex gain and the transfer function modulus between spontaneous RR interval and blood pressure fluctuations in 18 healthy subjects (age: 39±10 yrs., BMI: 26±4.9). The transfer function was calculated over the low-frequency range of the RR interval and systolic blood pressure oscillations during random-frequency paced breathing. The average modified Oxford baroreflex gain was lower than the average transfer function modulus (15.7±9.2 ms/mmHg vs. 19.4±10.5 ms/mmHg, P

Suggested Citation

  • Istvan Bonyhay & Marcelo Risk & Roy Freeman, 2013. "High-Pass Filter Characteristics of the Baroreflex – A Comparison of Frequency Domain and Pharmacological Methods," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0079513
    DOI: 10.1371/journal.pone.0079513
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    Cited by:

    1. Govindan, R.B. & Al-Shargabi, Tareq & Andescavage, Nickie N. & Metzler, Marina & Lenin, R.B. & Plessis, Adré du, 2017. "Assessing statistical significance of phase synchronization index — An application to study baroreflex function in critically-ill infants," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 465(C), pages 331-337.

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