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Genome-Wide Association Study of Breast Cancer in the Japanese Population

Author

Listed:
  • Siew-Kee Low
  • Atsushi Takahashi
  • Kyota Ashikawa
  • Johji Inazawa
  • Yoshio Miki
  • Michiaki Kubo
  • Yusuke Nakamura
  • Toyomasa Katagiri

Abstract

Breast cancer is the most common malignancy among women in worldwide including Japan. Several studies have identified common genetic variants to be associated with the risk of breast cancer. Due to the complex linkage disequilibrium structure and various environmental exposures in different populations, it is essential to identify variants associated with breast cancer in each population, which subsequently facilitate the better understanding of mammary carcinogenesis. In this study, we conducted a genome-wide association study (GWAS) as well as whole-genome imputation with 2,642 cases and 2,099 unaffected female controls. We further examined 13 suggestive loci (P

Suggested Citation

  • Siew-Kee Low & Atsushi Takahashi & Kyota Ashikawa & Johji Inazawa & Yoshio Miki & Michiaki Kubo & Yusuke Nakamura & Toyomasa Katagiri, 2013. "Genome-Wide Association Study of Breast Cancer in the Japanese Population," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0076463
    DOI: 10.1371/journal.pone.0076463
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    Cited by:

    1. Miki Watanabe & Satoyo Hosono & Hiroko Nakagawa-Senda & Sachiyo Yamamoto & Masami Aoyama & Satoru Hattori & Tamaki Yamada & Sadao Suzuki, 2021. "Does Direct-to-Consumer Personal Genetic Testing Improve Gynecological Cancer Screening Uptake among Never-Screened Attendees? A Randomized Controlled Study," IJERPH, MDPI, vol. 18(23), pages 1-10, November.

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