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MGMT Leu84Phe Polymorphism Contributes to Cancer Susceptibility: Evidence from 44 Case-Control Studies

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  • Jun Liu
  • Renxia Zhang
  • Fei Chen
  • Cuicui Yu
  • Yan Sun
  • Chuanliang Jia
  • Lijing Zhang
  • Taufiq Salahuddin
  • Xiaodong Li
  • Juntian Lang
  • Xicheng Song

Abstract

Background: O6-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent. Methods: We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. Results: Overall, significant association of the T allele with cancer susceptibility was verified with meta-analysis under a recessive genetic model (P

Suggested Citation

  • Jun Liu & Renxia Zhang & Fei Chen & Cuicui Yu & Yan Sun & Chuanliang Jia & Lijing Zhang & Taufiq Salahuddin & Xiaodong Li & Juntian Lang & Xicheng Song, 2013. "MGMT Leu84Phe Polymorphism Contributes to Cancer Susceptibility: Evidence from 44 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    • Handle: RePEc:plo:pone00:0075367
    DOI: 10.1371/journal.pone.0075367
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    1. Holger Schwender & Silvia Selinski & Meinolf Blaszkewicz & Rosemarie Marchan & Katja Ickstadt & Klaus Golka & Jan G Hengstler, 2012. "Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-12, December.
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