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Predictors of Raised Viral Load during Antiretroviral Therapy in Patients with and without Prior Antiretroviral Use: A Cross-Sectional Study

Author

Listed:
  • Jane E Greig
  • Philipp A du Cros
  • Clair Mills
  • Wilfred Ugwoeruchukwu
  • Andrew Etsetowaghan
  • Adetola Grillo
  • Adetoro Tayo-Adetoro
  • Kunle Omiyale
  • Tim Spelman
  • Daniel P O’Brien

Abstract

Objectives: In Lagos, Nigeria, Médecins Sans Frontières (MSF) and the Ministry of Health (MoH) commenced free antiretroviral treatment (ART) in a hospital-based clinic. We performed a cross-sectional study to compare factors associated with raised viral load between patients with (“experienced”) and without (“naïve”) prior antiretroviral (ARV) exposure at commencement of ART at the clinic. We also examined factors influencing ARV adherence in experienced patients prior to clinic entry. Methods: We included adult patients receiving ART from MSF who answered a questionnaire about previous antiretroviral use. Multivariate logistic regression was used to estimate odds ratios (OR) for raised viral load (≥1000 copies/mL). Results: 1246 (96%) patients answered: 1075 (86%) reported no, and 171 (14%) some, prior ARV exposure. ARV-naïve patients were more immunosuppressed at baseline: 65% vs 37% (p

Suggested Citation

  • Jane E Greig & Philipp A du Cros & Clair Mills & Wilfred Ugwoeruchukwu & Andrew Etsetowaghan & Adetola Grillo & Adetoro Tayo-Adetoro & Kunle Omiyale & Tim Spelman & Daniel P O’Brien, 2013. "Predictors of Raised Viral Load during Antiretroviral Therapy in Patients with and without Prior Antiretroviral Use: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-9, August.
    • Handle: RePEc:plo:pone00:0071407
    DOI: 10.1371/journal.pone.0071407
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    References listed on IDEAS

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    1. Sydney Rosen & Matthew P Fox & Christopher J Gill, 2007. "Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 4(10), pages 1-11, October.
    2. Ziad El-Khatib & David Katzenstein & Gaetano Marrone & Fatima Laher & Lerato Mohapi & Max Petzold & Lynn Morris & Anna Mia Ekström, 2011. "Adherence to Drug-Refill Is a Useful Early Warning Indicator of Virologic and Immunologic Failure among HIV Patients on First-Line ART in South Africa," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-10, March.
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