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The Association between Plasma 25-Hydroxyvitamin D and Subgroups in Age-Related Macular Degeneration: A Cross-Sectional Study

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  • Amardeep Singh
  • Mads Krüger Falk
  • Yousif Subhi
  • Torben Lykke Sørensen

Abstract

Objectives: To evaluate potential differences in plasma 25-hydroxyvitamin in subtypes of age-related macular degeneration (AMD), and in patients in Clinical Age-Related Maculopathy Staging (CARMS) group 5 with or without subretinal fibrosis. Methods: This single-center cross-sectional study included 178 participants during a period of 20 months. Ninety-five patients belonged to CARMS 5; twelve belonged to CARMS 4; twenty-two belonged to CARMS 2 or 3; and 49 individuals did not have AMD (CARMS 1). Following a structured interview, a detailed bilateral retinal examination was performed and participants were allocated to their respective subgroups in accordance with the Clinical Age-Related Maculopathy Staging system. Plasma 25-hydroxyvitamin D2 and D3 were analyzed using liquid chromatography-tandem mass spectrometry. Genomic DNA was extracted from leukocytes and genotyped for single nucleotide polymorphisms (SNPs) in the vitamin D metabolism. Differences in plasma 25-hydroxyvitamin D were determined in the subgroups as well as between patients in CARMS 5 with or without subretinal fibrosis. Results: Plasma 25-hydroxyvitamin D was comparable in patients across CARMS groups 1 to 5 (p = 0.83). In CARMS 5, the presence of subretinal fibrosis was associated with significantly lower concentrations of 25-hydroxyvitamin D as compared to the absence of subretinal fibrosis (47.2 versus 75.6 nmol/L, p

Suggested Citation

  • Amardeep Singh & Mads Krüger Falk & Yousif Subhi & Torben Lykke Sørensen, 2013. "The Association between Plasma 25-Hydroxyvitamin D and Subgroups in Age-Related Macular Degeneration: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0070948
    DOI: 10.1371/journal.pone.0070948
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    1. Schechtman, K.B. & Barzilai, B. & Rost, K. & Fisher Jr., E.B., 1991. "Measuring physical activity with a single question," American Journal of Public Health, American Public Health Association, vol. 81(6), pages 771-773.
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