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Indacaterol for Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis

Author

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  • Vincent C H Chung
  • Polly H X Ma
  • David S C Hui
  • Wilson W S Tam
  • Jin Ling Tang

Abstract

Background: Inhaled bronchodilators are the first-line therapy for COPD. Indacaterol is a novel addition to existing long-acting bronchodilators. Objectives: Systematic review of randomized controlled trials (RCT) on efficacy and safety of indacaterol as compared: 1) with placebo at different dosages, 2) with existing bronchodilators; (3) as add-on treatment to tiotropium. Methods: We searched 13 electronic databases, including MEDLINE, EMBASE and CENTRAL, and contacted the manufacturer for unpublished data. Primary outcome was mean FEV1 change at 12th week, secondary outcomes included changes in SGRQ, TDI and BODE index at 6 months, exacerbation at 1 year, and worsening of symptoms. Results: Twelve eligible RCTs of moderate risk of bias included data from 10,977 patients. Compared to placebo, indacaterol improved FEV1 by a weighted mean difference (WMD) of 0.16 L (95%CI: 0.15, 0.18 L, p

Suggested Citation

  • Vincent C H Chung & Polly H X Ma & David S C Hui & Wilson W S Tam & Jin Ling Tang, 2013. "Indacaterol for Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0070784
    DOI: 10.1371/journal.pone.0070784
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    Cited by:

    1. Jung Soo Kim & Jinkyeong Park & Seong Yong Lim & Yeon-Mok Oh & Kwang Ha Yoo & Yong Bum Park & Seung Soo Sheen & Min-Ji Kim & K C Carriere & Ji Ye Jung & Hye Yun Park, 2015. "Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-12, March.

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