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Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms

Author

Listed:
  • Linlin Tang
  • Lingyan Wang
  • Qi Liao
  • Qinwen Wang
  • Leiting Xu
  • Shizhong Bu
  • Yi Huang
  • Cheng Zhang
  • Huadan Ye
  • Xuting Xu
  • Qiong Liu
  • Meng Ye
  • Yifeng Mai
  • Shiwei Duan

Abstract

Aims: The goal of our study is to investigate the combined contribution of 10 genetic variants to diabetes susceptibility. Methods: Bibliographic databases were searched from 1970 to Dec 2012 for studies that reported on genetic association study of diabetes. After a comprehensive filtering procedure, 10 candidate gene variants with informative genotype information were collected for the current meta-anlayses. Using the REVMAN software, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the combined contribution of the selected genetic variants to diabetes. Results: A total of 37 articles among 37,033 cases and 54,716 controls were involved in the present meta-analyses of 10 genetic variants. Three variants were found to be significantly associated with type 1 diabetes (T1D): NLRP1 rs12150220 (OR = 0.71, 95% CI = 0.55–0.92, P = 0.01), IL2RA rs11594656 (OR = 0.86, 95% CI = 0.82–0.91, P

Suggested Citation

  • Linlin Tang & Lingyan Wang & Qi Liao & Qinwen Wang & Leiting Xu & Shizhong Bu & Yi Huang & Cheng Zhang & Huadan Ye & Xuting Xu & Qiong Liu & Meng Ye & Yifeng Mai & Shiwei Duan, 2013. "Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0070301
    DOI: 10.1371/journal.pone.0070301
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    References listed on IDEAS

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    1. Hakon Hakonarson & Struan F. A. Grant & Jonathan P. Bradfield & Luc Marchand & Cecilia E. Kim & Joseph T. Glessner & Rosemarie Grabs & Tracy Casalunovo & Shayne P. Taback & Edward C. Frackelton & Marg, 2007. "A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene," Nature, Nature, vol. 448(7153), pages 591-594, August.
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