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A Novel Approach to Accounting for Loss to Follow-Up when Estimating the Relationship between CD4 Count at ART Initiation and Mortality

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  • Matthew Fox
  • Owen McCarthy
  • Mead Over

Abstract

Background: While CD4 strongly predicts mortality on antiretroviral therapy (ART), estimates from programmatic data suffer from incomplete patient outcomes. Methods: We conducted a pooled analysis of one-year mortality data on ART accounting for lost patients. We identified articles reporting one-year mortality by ART initiation CD4 count. We estimated the average mortality among those lost as the value that maximizes the fit of a regression of the natural log of mortality on the natural log of the imputed mean CD4 count in each band. Results: We found 20 studies representing 64,426 subjects and 51 CD4 observations. Without correcting for losses, one-year mortality was >4.8% for all CD4 counts 500 had a one-year mortality

Suggested Citation

  • Matthew Fox & Owen McCarthy & Mead Over, 2013. "A Novel Approach to Accounting for Loss to Follow-Up when Estimating the Relationship between CD4 Count at ART Initiation and Mortality," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0069300
    DOI: 10.1371/journal.pone.0069300
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    1. repec:bla:devpol:v:24:y:2006:i:3:p:321-337 is not listed on IDEAS
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    Cited by:

    1. Annisa Rahmalia & Michael Holton Price & Yovita Hartantri & Bachti Alisjahbana & Rudi Wisaksana & Reinout van Crevel & Andre J A M van der Ven, 2019. "Are there differences in HIV retention in care between female and male patients in Indonesia? A multi-state analysis of a retrospective cohort study," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-17, June.

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