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Methadone Maintenance Treatment Participant Retention and Behavioural Effectiveness in China: A Systematic Review and Meta-Analysis

Author

Listed:
  • Lei Zhang
  • Eric P F Chow
  • Xun Zhuang
  • Yanxian Liang
  • Yafei Wang
  • Caiyun Tang
  • Li Ling
  • Joseph D Tucker
  • David P Wilson

Abstract

Background: Methadone maintenance treatment (MMT) has been scaled up by the Chinese government alongside persistent compulsory drug user detention, but the extent to which detention interferes with MMT is unknown. The study systematically reviews Chinese MMT retention rates, reasons for drop out, and behavioural changes. Method: Chinese and English databases of literature are searched for studies reporting retention rates, drug use and sexual behaviours among MMT participants in China between 2004 and 2013. The estimates are summarized through a systematic review and meta-analysis. Results: A total of 74 studies representing 43,263 individuals are included in this analysis. About a third of MMT participants drop out during the first three months of treatment (retention rate 69.0% (95% CI 57.7-78.4%)). Police arrest and detention in compulsory rehabilitation was the most common cause of drop out, accounting for 22.2% of all those not retained. Among retained participants, changing unsafe drug use behaviours was more effective than changing unsafe sexual behaviours. At 12 months following MMT initiation, 24.6% (15.7-33.5%) of MMT participants had a positive urine test, 9.3% (4.7-17.8%) injected drugs and only 1.1% (0.4-3.0%) sold sex for drugs. These correspond to 0.002 (

Suggested Citation

  • Lei Zhang & Eric P F Chow & Xun Zhuang & Yanxian Liang & Yafei Wang & Caiyun Tang & Li Ling & Joseph D Tucker & David P Wilson, 2013. "Methadone Maintenance Treatment Participant Retention and Behavioural Effectiveness in China: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-1, July.
    • Handle: RePEc:plo:pone00:0068906
    DOI: 10.1371/journal.pone.0068906
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    Cited by:

    1. Lei Zhang & Lorraine Yap & Joanne Reekie & Wei Liu & Yi Chen & Zunyou Wu & Handan Wand & Tony Butler, 2015. "Drug Use and HIV Infection Status of Detainees in Re-Education through Labour Camps in Guangxi Province, China," IJERPH, MDPI, vol. 12(5), pages 1-18, April.
    2. Xiaoyan Fan & Xiao Zhang & Huifang Xu & Fan Yang & Joseph T.F. Lau & Chun Hao & Jinghua Li & Yuteng Zhao & Yuantao Hao & Jing Gu, 2019. "Effectiveness of a Psycho-Social Intervention Aimed at Reducing Attrition at Methadone Maintenance Treatment Clinics: A Propensity Score Matching Analysis," IJERPH, MDPI, vol. 16(22), pages 1-15, November.
    3. Kaina Zhou & Duolao Wang & Hengxin Li & Xiaoli Wei & Juan Yin & Peifeng Liang & Lingling Kou & Mengmeng Hao & Lijuan You & Xiaomei Li & Guihua Zhuang, 2017. "Bidirectional relationships between retention and health-related quality of life in Chinese mainland patients receiving methadone maintenance treatment," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-12, June.

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