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Lack of Association of MiR-34b/c Polymorphism (rs4938723) with Hepatocellular Carcinoma: A Meta-Analysis

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  • Tie-Jun Liang
  • Hong-Jun Liu
  • Xiao-Qian Zhao
  • Cui-Hua Yu
  • Chen-Sheng Li

Abstract

Background: Previous studies have focused on the association of miR-34 family members with carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). It has been suggested that miR-34b/c polymorphism (rs4938723) is associated with susceptibility to HCC. In the present study, we performed a meta-analysis to systematically summarize the possible association between rs4938723 and the risk for HCC. Methodology/Principal Findings: We conducted a search of case-control studies on the associations of rs4938723 with susceptibility to HCC in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library, Wangfang database in China, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. HCC risk associated with rs4938723 was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). 3 studies on rs4938723 were included in our meta-analysis. Our results showed that neither allele frequency nor genotype distribution of the rs4938723 was associated with risk for HCC in all genetic models. Conclusions/Significance: This meta-analysis suggests that rs4938723 is not associated with the risk of HCC. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

Suggested Citation

  • Tie-Jun Liang & Hong-Jun Liu & Xiao-Qian Zhao & Cui-Hua Yu & Chen-Sheng Li, 2013. "Lack of Association of MiR-34b/c Polymorphism (rs4938723) with Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-5, July.
    • Handle: RePEc:plo:pone00:0068588
    DOI: 10.1371/journal.pone.0068588
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    1. Yifang Han & Rui Pu & Xue Han & Jun Zhao & Yuwei Zhang & Qi Zhang & Jianhua Yin & Jiaxin Xie & Qiuxia Shen & Yang Deng & Yibo Ding & Weiping Li & Juhong Li & Hongwei Zhang & Guangwen Cao, 2013. "Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-9, March.
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