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Prognostic Significance of HIF-1α Expression in Hepatocellular Carcinoma: A Meta-Analysis

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  • Su-Su Zheng
  • Xiao-Hong Chen
  • Xin Yin
  • Bo-Heng Zhang

Abstract

Aim: Pilot studies have evaluated the correlation between hypoxia-inducible factor-1α (HIF-1α) overexpression and clinical outcome in hepatocellular carcinoma (HCC) patients. However, the results remain inconclusive. To comprehensively and quantitatively summarize the evidence on the suitability of HIF-1α to predict the prognosis of patients with HCC, a meta-analysis was carried out. Methods: Systematic literature searches were applied to PubMed, Elsevier and Web of Science databases until Feb. 2013. Seven studies (953 patients) were included in this meta-analysis. Pooled measure was calculated from the available data to evaluate the association between tissue -based HIF-1α level and overall survival (OS) and disease-free survival (DFS) in HCC patients. The relation between HIF-1α expression and vascular invasion was also assessed. Data were synthesized with fixed or random effect model, hazard ration (HR) or odds ratio (OR) with its 95% confidence interval (CI) was used as the effect size estimate. Result: The combined data suggested that HIF-1α overexpression in HCC correlated with poor OS [HR = 1.65 (95% (CI): 1.38, 1.97)] and DFS [HR = 2.14 (95% CI: 1.39, 3.29)]. And high HIF-1α expression tended to be associated with vascular invasion [OR = 2.21 (95% CI: 1.06, 4.57)]. Conclusion: HIF-1α overexpression indicates a poor prognosis for patients with HCC, it may also have predictive potential for HCC invasion and metastasis.

Suggested Citation

  • Su-Su Zheng & Xiao-Hong Chen & Xin Yin & Bo-Heng Zhang, 2013. "Prognostic Significance of HIF-1α Expression in Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0065753
    DOI: 10.1371/journal.pone.0065753
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    1. Lin Zhao & Aihua Gu & Guixiang Ji & Peng Zou & Peng Zhao & Ailin Lu, 2012. "The Association between ATM IVS 22-77 T>C and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
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    Cited by:

    1. Jing Chen & Tao Li & Qilun Liu & Haiyan Jiao & Wenjun Yang & Xiaoxia Liu & Zhenghao Huo, 2014. "Clinical and Prognostic Significance of HIF-1α, PTEN, CD44v6, and Survivin for Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-15, March.

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