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Age at Menarche and Risk of Colorectal Cancer: A Meta-Analysis

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  • Chun-Yan Li
  • Bo Song
  • Ying-Yan Wang
  • Hua Meng
  • Shi-Bin Guo
  • Li-Na Liu
  • Hai-Chen Lv
  • Qi-Jun Wu

Abstract

Background: Various observational studies have focused on the relationship between menarcheal age and the risk of colorectal cancer (CRC). However, the association is still controversial because of inconsistent results. Therefore, we performed a meta-analysis to assess this issue from epidemiological studies. Methods: After a literature search in MEDLINE, EMBASE, and Web of Science for studies of menarcheal age and CRC risk published through the end of January 2013, we pooled the relative risks (RRs) from included studies using a fixed- or random-effects model and performed heterogeneity and publication bias analyses. All statistical tests were two-sided. Results: Eleven case-control and 11 cohort studies were eligible for inclusion in our analysis. The random-effects pooled RR for oldest versus youngest menarcheal age was 0.95 [95% confidence intervals (CIs) = 0.85–1.06], with significant heterogeneity (Q = 61.03, P

Suggested Citation

  • Chun-Yan Li & Bo Song & Ying-Yan Wang & Hua Meng & Shi-Bin Guo & Li-Na Liu & Hai-Chen Lv & Qi-Jun Wu, 2013. "Age at Menarche and Risk of Colorectal Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0065645
    DOI: 10.1371/journal.pone.0065645
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    Cited by:

    1. Gemma L. Clayton & Maria Carolina Borges & Deborah A. Lawlor, 2024. "The impact of reproductive factors on the metabolic profile of females from menarche to menopause," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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