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The Geometric Increase in Meta-Analyses from China in the Genomic Era

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  • John P A Ioannidis
  • Christine Q Chang
  • Tram Kim Lam
  • Sheri D Schully
  • Muin J Khoury

Abstract

Meta-analyses are increasingly popular. It is unknown whether this popularity is driven by specific countries and specific meta-analyses types. PubMed was used to identify meta-analyses since 1995 (last update 9/1/2012) and catalogue their types and country of origin. We focused more on meta-analyses from China (the current top producer of meta-analyses) versus the USA (top producer until recently). The annual number of meta-analyses from China increased 40-fold between 2003 and 2011 versus 2.4-fold for the USA. The growth of Chinese meta-analyses was driven by genetics (110-fold increase in 2011 versus 2003). The HuGE Navigator identified 612 meta-analyses of genetic association studies published in 2012 from China versus only 109 from the USA. We compared in-depth 50 genetic association meta-analyses from China versus 50 from USA in 2012. Meta-analyses from China almost always used only literature-based data (92%), and focused on one or two genes (94%) and variants (78%) identified with candidate gene approaches (88%), while many USA meta-analyses used genome-wide approaches and raw data. Both groups usually concluded favorably for the presence of genetic associations (80% versus 74%), but nominal significance (P

Suggested Citation

  • John P A Ioannidis & Christine Q Chang & Tram Kim Lam & Sheri D Schully & Muin J Khoury, 2013. "The Geometric Increase in Meta-Analyses from China in the Genomic Era," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0065602
    DOI: 10.1371/journal.pone.0065602
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    Cited by:

    1. Diego A Forero & Sandra Lopez-Leon & Yeimy González-Giraldo & Pantelis G Bagos, 2019. "Ten simple rules for carrying out and writing meta-analyses," PLOS Computational Biology, Public Library of Science, vol. 15(5), pages 1-7, May.
    2. Wei Chen & Qin-Rui Xing & Hui Wang & Tao Wang, 2018. "Retracted publications in the biomedical literature with authors from mainland China," Scientometrics, Springer;Akadémiai Kiadó, vol. 114(1), pages 217-227, January.

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