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Screening for EGFR Amplifications with a Novel Method and Their Significance for the Outcome of Glioblastoma Patients

Author

Listed:
  • Michał Bieńkowski
  • Sylwester Piaskowski
  • Ewelina Stoczyńska-Fidelus
  • Małgorzata Szybka
  • Mateusz Banaszczyk
  • Monika Witusik-Perkowska
  • Emilia Jesień-Lewandowicz
  • Dariusz J Jaskólski
  • Anna Radomiak-Załuska
  • Dorota Jesionek-Kupnicka
  • Beata Sikorska
  • Wielisław Papierz
  • Piotr Rieske
  • Paweł P Liberski

Abstract

Glioblastoma is a highly aggressive tumour of the central nervous system, characterised by poor prognosis irrespective of the applied treatment. The aim of our study was to analyse whether the molecular markers of glioblastoma (i.e. TP53 and IDH1 mutations, CDKN2A deletion, EGFR amplification, chromosome 7 polysomy and EGFRvIII expression) could be associated with distinct prognosis and/or response to the therapy. Moreover, we describe a method which allows for a reliable, as well as time- and cost-effective, screening for EGFR amplification and chromosome 7 polysomy with quantitative Real-Time PCR at DNA level. In the clinical data, only the patient’s age had prognostic significance (continuous: HR = 1.04; p

Suggested Citation

  • Michał Bieńkowski & Sylwester Piaskowski & Ewelina Stoczyńska-Fidelus & Małgorzata Szybka & Mateusz Banaszczyk & Monika Witusik-Perkowska & Emilia Jesień-Lewandowicz & Dariusz J Jaskólski & Anna Radom, 2013. "Screening for EGFR Amplifications with a Novel Method and Their Significance for the Outcome of Glioblastoma Patients," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0065444
    DOI: 10.1371/journal.pone.0065444
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    References listed on IDEAS

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    1. Franck Rapaport & Christina Leslie, 2010. "Determining Frequent Patterns of Copy Number Alterations in Cancer," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-10, August.
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