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Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology

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Listed:
  • Fanggeng Zou
  • Olivia Belbin
  • Minerva M Carrasquillo
  • Oliver J Culley
  • Talisha A Hunter
  • Li Ma
  • Gina D Bisceglio
  • Mariet Allen
  • Dennis W Dickson
  • Neill R Graff-Radford
  • Ronald C Petersen
  • the Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium
  • Kevin Morgan
  • Steven G Younkin

Abstract

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer’s disease (LOAD) with reported odds ratios (ORs) ranging from 0.75–0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61–1.20) with no significant association (all p>0.32). Four variants were hetergeneous across the populations (all p

Suggested Citation

  • Fanggeng Zou & Olivia Belbin & Minerva M Carrasquillo & Oliver J Culley & Talisha A Hunter & Li Ma & Gina D Bisceglio & Mariet Allen & Dennis W Dickson & Neill R Graff-Radford & Ronald C Petersen & th, 2013. "Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0064802
    DOI: 10.1371/journal.pone.0064802
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    1. Xiaolan Hu & Eve Pickering & Yingxue Cathy Liu & Stephanie Hall & Helene Fournier & Elyse Katz & Bryan Dechairo & Sally John & Paul Van Eerdewegh & Holly Soares & the Alzheimer's Disease Neuroimaging , 2011. "Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-9, February.
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