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Meta-Analysis of the Association between Insulin-Like Growth Factor Binding Protein 3 Genetic Polymorphisms and Colorectal Cancer Susceptibility

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  • Hao Xiang
  • Ying Wang
  • Shaofa Nie

Abstract

Insulin-like growth factor binding protein 3 (IGFBP-3) plays an important role in the development and progress of cancers. The association between IGFBP-3 polymorphisms and colorectal cancer remains controversial and ambiguous. The aim of this study is to explore the association between IGFBP3 A-202C and Gly32Ala polymorphisms and colorectal cancer susceptibility using meta-analyisi. Case-control studies on the association between IGFBP3 A-202C and Gly32Ala polymorphisms and colorectal cancer, which had sufficient data for estimating an odds ratio (OR) with 95% confidence interval (CI), were included in the meta-analysis. Abstracts, case reports, editorials, and review articles were excluded. Heterozygous and homozygous mutants were compared with the wild types to estimate combined OR values and 95%CIs with Review Manager 5.0. Six eligible studies were included, with 3157 patients and 6027 controls for A-202C and 1711 patients and 2995 controls for Gly32Ala. No significant association was found in all genetic models (for A-202C, AC vs. AA, OR = 0.99(0.88–1.11), CC vs. AA, OR = 1.06(0.92–1.22), dominant model, OR = 0.98(0.88–1.09), recessive model, OR = 0.94(0.84–1.05); and for Gly32Ala polymorphism, GC vs. GG, OR = 1.10(0.92–1.31), CC vs. GG, OR = 0.93(0.76–1.14), dominant model, OR = 1.05(0.89–1.24), recessive model, OR = 0.90(0.77–1.05)). The results suggest that the IGFBP3 A-202C and Gly32Ala polymorphisms are not associated with colorectal cancer susceptibility.

Suggested Citation

  • Hao Xiang & Ying Wang & Shaofa Nie, 2013. "Meta-Analysis of the Association between Insulin-Like Growth Factor Binding Protein 3 Genetic Polymorphisms and Colorectal Cancer Susceptibility," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0059665
    DOI: 10.1371/journal.pone.0059665
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    Cited by:

    1. Hua Zhao & Kui-Jie Liu & Zhen-Dong Lei & San-Lin Lei & Yong-Quan Tian, 2014. "Meta-Analysis of the Aldehyde Dehydrogenases-2 (ALDH2) Glu487Lys Polymorphism and Colorectal Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.

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