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A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure

Author

Listed:
  • Ruyang Zhang
  • Yang Zhao
  • Minjie Chu
  • Amar Mehta
  • Yongyue Wei
  • Yao Liu
  • Pengcheng Xun
  • Jianling Bai
  • Hao Yu
  • Li Su
  • Hongxi Zhang
  • Zhibin Hu
  • Hongbing Shen
  • Feng Chen
  • David C Christiani

Abstract

Background: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood. Objective: We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in newly-hired healthy young female cotton textile workers. Methods: DNA samples were genotyped using the Illumina Human CVD BeadChip. Change rate in FEV1 was modeled as a function of each SNP genotype in linear regression model with covariate adjustment. We controlled the type 1 error in study-wide level by permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively. Results: Two SNPs were found to be significant (P

Suggested Citation

  • Ruyang Zhang & Yang Zhao & Minjie Chu & Amar Mehta & Yongyue Wei & Yao Liu & Pengcheng Xun & Jianling Bai & Hao Yu & Li Su & Hongxi Zhang & Zhibin Hu & Hongbing Shen & Feng Chen & David C Christiani, 2013. "A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0059035
    DOI: 10.1371/journal.pone.0059035
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