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The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis

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  • Shi Guang Li
  • Hai Yong Chen
  • Chen Sheng Ou-Yang
  • Xi-Xin Wang
  • Zhen-Jiang Yang
  • Yao Tong
  • William CS Cho

Abstract

Many published studies reflect the growing application of complementary and alternative medicine, particularly Chinese herbal medicine (CHM) use in combination with conventional cancer therapy for advanced non-small cell lung cancer (NSCLC), but its efficacy remains largely unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with conventional chemotherapy (CT) in the treatment of advanced NSCLC. Publications in 11 electronic databases were extensively searched, and 24 trials were included for analysis. A sum of 2,109 patients was enrolled in these studies, at which 1,064 patients participated in CT combined CHM and 1,039 in CT (six patients dropped out and were not reported the group enrolled). Compared to using CT alone, CHM combined with CT significantly increase one-year survival rate (RR = 1.36, 95% CI = 1.15–1.60, p = 0.0003). Besides, the combined therapy significantly increased immediate tumor response (RR = 1.36, 95% CI = 1.19–1.56, p

Suggested Citation

  • Shi Guang Li & Hai Yong Chen & Chen Sheng Ou-Yang & Xi-Xin Wang & Zhen-Jiang Yang & Yao Tong & William CS Cho, 2013. "The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0057604
    DOI: 10.1371/journal.pone.0057604
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    Cited by:

    1. Cao dedong & Xu huilin & He Anbing & Xu Ximing & Ge wei, 2016. "The Effect of ShenQi FuZheng Injection in Combination with Chemotherapy versus Chemotherapy Alone on the Improvement of Efficacy and Immune Function in Patients with Advanced Non-Small Cell Lung Cance," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-16, March.

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