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Dose–Risk and Duration–Risk Relationships between Aspirin and Colorectal Cancer: A Meta-Analysis of Published Cohort Studies

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  • Xiaohua Ye
  • Jinjian Fu
  • Yi Yang
  • Sidong Chen

Abstract

Background: In previous meta-analyses, aspirin use has been associated with reduced risk of colorectal cancer. However, uncertainty remains on the exact dose–risk and duration–risk relationships. Methods: We identified studies by searching several English and Chinese electronic databases and reviewing relevant articles. The dose-response meta-analysis was performed by linear trend regression and restricted cubic spline regression. Subgroup analyses were conducted to explore possible heterogeneity among studies. Potential heterogeneity was calculated as Q statistic and I2 value. Publication bias was evaluated using funnel plots and quantified by the Begg’s and Egger’s test. Results: Twelve studies were included in this meta-analysis. An inverse association between aspirin use and colorectal cancer was observed in both the overall group (RR = 0.74, 95% CI 0.64–0.83 for aspirin dose; RR = 0.80, 95% CI 0.75–0.85 for frequency of aspirin use; RR = 0.75, 95% CI 0.68–0.81 for years of aspirin use) and subgroups stratified by sex and cancer site. The dose-response meta-analysis showed that there was a 20% statistically significant decreased risk of colorectal cancer for 325 mg aspirin per day increment, 18% decreased risk for 7 times aspirin per week increment and 18% decreased risk for 10 years aspirin increment. Conclusion: Long-term (>5 years), low-dose (75–325 mg per day) and regular aspirin use (2–7 times per week) can effectively reduce the risk of colorectal cancer.

Suggested Citation

  • Xiaohua Ye & Jinjian Fu & Yi Yang & Sidong Chen, 2013. "Dose–Risk and Duration–Risk Relationships between Aspirin and Colorectal Cancer: A Meta-Analysis of Published Cohort Studies," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-10, February.
  • Handle: RePEc:plo:pone00:0057578
    DOI: 10.1371/journal.pone.0057578
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    Cited by:

    1. Changlin Han & Yangqun Liu & Xiao Gong & Xiaohua Ye & Junli Zhou, 2019. "Relationship between Secondhand Smoke Exposure and Depressive Symptoms: A Systematic Review and Dose–Response Meta-Analysis," IJERPH, MDPI, vol. 16(8), pages 1-14, April.
    2. Xiaohua Ye & Jinjian Fu & Yi Yang & Yanhui Gao & Li Liu & Sidong Chen, 2013. "Frequency-Risk and Duration-Risk Relationships between Aspirin Use and Gastric Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.

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