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Measurement of Variceal Pressure with a Computerized Endoscopic Manometry: Validation and Effect of Propranolol Therapy in Cirrhotic Patients

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  • De-Run Kong
  • Chao Zhang
  • Lei Zhang
  • Jing-Guang Wang
  • Zhuang Xiong
  • Pan Li
  • Jian-Ming Xu

Abstract

Background and Purpose: Recently, we invented a computerized endoscopic balloon manometry (CEBM) to measure variceal pressure (VP) in cirrhotic patient. The purpose of this study was to evaluate the reliability and feasibility of this method, and whether this technique provided further information to pharmacological therapy. Patients and Methods: VP measurements were performed in 83 cirrhotic patients and compared with HVPG as well as endoscopic bleeding risk parameters. Furthermore, VP was assessed before and during propranolol therapy in 30 patients without previous bleeding. Results: VP measurements were successful in 96% (83/86) of all patients. Of the 83 patients, the VP correlated closely with the HVPG (P

Suggested Citation

  • De-Run Kong & Chao Zhang & Lei Zhang & Jing-Guang Wang & Zhuang Xiong & Pan Li & Jian-Ming Xu, 2013. "Measurement of Variceal Pressure with a Computerized Endoscopic Manometry: Validation and Effect of Propranolol Therapy in Cirrhotic Patients," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0056332
    DOI: 10.1371/journal.pone.0056332
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