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52-Week Efficacy and Safety of Telbivudine with Conditional Tenofovir Intensification at Week 24 in HBeAg-Positive Chronic Hepatitis B

Author

Listed:
  • Teerha Piratvisuth
  • Piyawat Komolmit
  • Tawesak Tanwandee
  • Wattana Sukeepaisarnjaroen
  • Henry L Y Chan
  • Mário G Pessôa
  • Eduardo Fassio
  • Suzane K Ono
  • Fernando Bessone
  • Jorge Daruich
  • Stefan Zeuzem
  • Hugo Cheinquer
  • Rashidkhan Pathan
  • Yuhong Dong
  • Aldo Trylesinski

Abstract

Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response. The efficacy and safety of this approach applied to telbivudine treatment has not been investigated. Methods: A multinational, phase IV, single-arm open-label study (ClinicalTrials.gov ID NCT00651209) was undertaken in HBeAg-positive, nucleoside-naive adult patients with chronic hepatitis B. Patients received telbivudine (600 mg once-daily) for 24 weeks, after which those with undetectable serum HBV DNA (

Suggested Citation

  • Teerha Piratvisuth & Piyawat Komolmit & Tawesak Tanwandee & Wattana Sukeepaisarnjaroen & Henry L Y Chan & Mário G Pessôa & Eduardo Fassio & Suzane K Ono & Fernando Bessone & Jorge Daruich & Stefan Zeu, 2013. "52-Week Efficacy and Safety of Telbivudine with Conditional Tenofovir Intensification at Week 24 in HBeAg-Positive Chronic Hepatitis B," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0054279
    DOI: 10.1371/journal.pone.0054279
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