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Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies

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  • Yanlei Ma
  • Yongzhi Yang
  • Feng Wang
  • Peng Zhang
  • Chenzhang Shi
  • Yang Zou
  • Huanlong Qin

Abstract

Background: Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis. Methodology/Principal Findings: Relevant studies were identified by a search of MEDLINE and EMBASE databases before January 2012, with no restrictions. We also reviewed reference lists from retrieved articles. We included prospective studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between general obesity [measured using body mass index (BMI)] or central obesity [measured using waist circumference (WC)] and the risk of colorectal, colon, or rectal cancer. Approximately 9, 000, 000 participants from several countries were included in this analysis. 41 studies on general obesity and 13 studies on central obesity were included in the meta-analysis. The pooled RRs of CRC for the obese vs. normal category of BMI were 1.334 (95% CI, 1.253–1.420), and the highest vs. lowest category of WC were 1.455 (95% CI, 1.327–1.596). There was heterogeneity among studies of BMI (P

Suggested Citation

  • Yanlei Ma & Yongzhi Yang & Feng Wang & Peng Zhang & Chenzhang Shi & Yang Zou & Huanlong Qin, 2013. "Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-1, January.
    • Handle: RePEc:plo:pone00:0053916
    DOI: 10.1371/journal.pone.0053916
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    Cited by:

    1. Nikolaos Pararas & Anastasia Pikouli & Dionysios Dellaportas & Constantinos Nastos & Anestis Charalampopoulos & Mohamad Ayham Muqresh & George Bagias & Emmanouil Pikoulis & Dimitrios Papaconstantinou, 2023. "The Protective Effect of Bariatric Surgery on the Development of Colorectal Cancer: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(5), pages 1-12, February.
    2. Sunday Azagba & Lingpeng Shan & Keely Latham, 2019. "Overweight and Obesity among Sexual Minority Adults in the United States," IJERPH, MDPI, vol. 16(10), pages 1-9, May.
    3. Sida Zhuang & Gabriele Bolte & Tobia Lakes, 2022. "Exploring Environmental Health Inequalities: A Scientometric Analysis of Global Research Trends (1970–2020)," IJERPH, MDPI, vol. 19(12), pages 1-25, June.
    4. Stewart Rose & Amanda Strombom, 2019. "Colorectal Cancer Prevention with a Plant-Based Diet," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 15(2), pages 50-67, October.
    5. Junga Lee & Jeffrey A Meyerhardt & Edward Giovannucci & Justin Y Jeon, 2015. "Association between Body Mass Index and Prognosis of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-25, March.

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