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Prognostic Value of Malondialdehyde Serum Levels in Severe Sepsis: A Multicenter Study

Author

Listed:
  • Leonardo Lorente
  • María M Martín
  • Pedro Abreu-González
  • Alberto Domínguez-Rodríguez
  • Lorenzo Labarta
  • César Díaz
  • Jordi Solé-Violán
  • José Ferreres
  • Juan María Borreguero-León
  • Alejandro Jiménez
  • Armando Morera-Fumero

Abstract

Objective: The oxidant/antioxidant state in septic patients has only been studied in small series. We wished to determine whether malondialdehyde (MDA) serum levels were associated with severity and 30-day mortality in a large series of patients with sepsis. Methods: We performed an observational, prospective, multicenter study in six Spanish Intensive Care Units. Serum levels of MDA were measured in a total of 228 patients (145 survivors and 83 non-survivors) with severe sepsis and 100 healthy controls. Results: Serum levels of MDA were higher in severe septic patients than in healthy controls. Non-surviving septic patients had higher MDA values than survivors. MDA serum levels were associated with severity markers (lactic acid, SOFA, APACHE-II) and coagulation indices. Regression analysis showed that MDA serum levels were associated with 30-day survival (Hazard ratio = 1.05; 95% confidence interval = 1.009–1.091; p = 0.016). Receiver operating characteristic analysis showed that the area under curve of MDA serum levels to predict 30-day survival was 0.62 (95% CI = 0.56–0.69; P = 0.002). The risk of death in septic patients with MDA serum levels above 4.11 nmol/mL was higher than in patients with lower values (Hazard Ratio = 2.43; 95% CI = 1.49–3.94; p

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  • Leonardo Lorente & María M Martín & Pedro Abreu-González & Alberto Domínguez-Rodríguez & Lorenzo Labarta & César Díaz & Jordi Solé-Violán & José Ferreres & Juan María Borreguero-León & Alejandro Jimén, 2013. "Prognostic Value of Malondialdehyde Serum Levels in Severe Sepsis: A Multicenter Study," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-5, January.
    • Handle: RePEc:plo:pone00:0053741
    DOI: 10.1371/journal.pone.0053741
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    1. Leonardo Lorente & María M Martín & Pedro Abreu-González & Luis Ramos & Mónica Argueso & Jordi Solé-Violán & Marta Riaño-Ruiz & Alejandro Jiménez, 2015. "Serum Malondialdehyde Levels in Patients with Malignant Middle Cerebral Artery Infarction Are Associated with Mortality," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-9, May.

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