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Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country

Author

Listed:
  • Clíona Ní Cheallaigh
  • Ian Fitzgerald
  • Jacinta Grace
  • Gurmit Jagjit Singh
  • Nahla El-Eraki
  • Noel Gibbons
  • Joseph Keane
  • Thomas R Rogers
  • Susan Clarke
  • Colm Bergin

Abstract

Background: Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting. Methodology/Principal Findings: T-SPOT.TB, QFT-IT, and tuberculin skin tests (TST) were performed in HIV infected individuals. Results were related to patient characteristics. McNemar’s test, multivariate regression and correlation analysis were carried out using SPSS (SPSS Inc). 256 HIV infected patients were enrolled in the study. The median CD4+ T-cell count was 338 cells/µL (range 1–1328). 37 (14%) patients had a CD4+ T-cell count of

Suggested Citation

  • Clíona Ní Cheallaigh & Ian Fitzgerald & Jacinta Grace & Gurmit Jagjit Singh & Nahla El-Eraki & Noel Gibbons & Joseph Keane & Thomas R Rogers & Susan Clarke & Colm Bergin, 2013. "Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0053330
    DOI: 10.1371/journal.pone.0053330
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    Cited by:

    1. Erfan Ayubi & Amin Doosti-Irani & Ali Sanjari Moghaddam & Mohadeseh Sani & Milad Nazarzadeh & Ehsan Mostafavi, 2016. "The Clinical Usefulness of Tuberculin Skin Test versus Interferon-Gamma Release Assays for Diagnosis of Latent Tuberculosis in HIV Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-13, September.

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