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Development and Validation of a Vitamin D Status Prediction Model in Danish Pregnant Women: A Study of the Danish National Birth Cohort

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  • Camilla Bjørn Jensen
  • Andrew L Thorne-Lyman
  • Linda Vadgård Hansen
  • Marin Strøm
  • Nina Odgaard Nielsen
  • Arieh Cohen
  • Sjurdur Frodi Olsen

Abstract

Vitamin D has been hypothesized to reduce risk of pregnancy complications such as preeclampsia, gestational diabetes mellitus, and preterm delivery. However, many of these outcomes are rare and require a large sample size to study, representing a challenge for cohorts with a limited number of preserved samples. The aims of this study were to (1) identify predictors of serum 25-hydroxy-vitamin D (25(OH)D) among pregnant women in a subsample (N = 1494) of the Danish National Birth Cohort (DNBC) and (2) develop and validate a score predicting 25(OH)D-status in order to explore associations between vitamin D and maternal and offspring health outcomes in the DNBC. In our study sample, 42.3% of the population had deficient levels of vitamin D (

Suggested Citation

  • Camilla Bjørn Jensen & Andrew L Thorne-Lyman & Linda Vadgård Hansen & Marin Strøm & Nina Odgaard Nielsen & Arieh Cohen & Sjurdur Frodi Olsen, 2013. "Development and Validation of a Vitamin D Status Prediction Model in Danish Pregnant Women: A Study of the Danish National Birth Cohort," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0053059
    DOI: 10.1371/journal.pone.0053059
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