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Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis

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  • Vanja M Dukic
  • Diane S Lauderdale
  • Jocelyn Wilder
  • Robert S Daum
  • Michael Z David

Abstract

Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began circulating. CA-MRSA infections are now common, resulting in serious and sometimes fatal infections in otherwise healthy people. Although some have suggested that there is an epidemic of CA-MRSA in the U.S., the origins, extent, and geographic variability of CA-MRSA infections are not known. We present a meta-analysis of published studies that included trend data from a single site or region, and derive summary epidemic curves of CA-MRSA spread over time. Our analysis reveals a dramatic increase in infections over the past two decades, with CA-MRSA strains now endemic at unprecedented levels in many US regions. This increase has not been geographically homogeneous, and appears to have occurred earlier in children than adults.

Suggested Citation

  • Vanja M Dukic & Diane S Lauderdale & Jocelyn Wilder & Robert S Daum & Michael Z David, 2013. "Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
    • Handle: RePEc:plo:pone00:0052722
    DOI: 10.1371/journal.pone.0052722
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    Cited by:

    1. Xiaoxia Wang & Sarada Panchanathan & Gerardo Chowell, 2013. "A Data-Driven Mathematical Model of CA-MRSA Transmission among Age Groups: Evaluating the Effect of Control Interventions," PLOS Computational Biology, Public Library of Science, vol. 9(11), pages 1-13, November.

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